
Legion KSM-66 Ashwagandha
- KSM-66 standardised extract
- Every dose disclosed
Guides, research reviews, comparisons, product recommendations and FAQs for ashwagandha.
The trials on this page all used KSM-66, the standardised root extract, at 300 mg twice daily. That is the extract and the dose in the product we use.


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Evidence-based beginner and intermediate guide.
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Explore ->Compare benefits, timing, dosage and alternatives.
Explore ->Practical answers to common questions.
Explore ->KSM-66 and Sensoril are the two clinically validated extracts. KSM-66 (full-spectrum root extract, 5% withanolides) has more RCT data on strength and cortisol. Sensoril (leaf+root, 10% withanolides) is preferred for sleep. For general use, KSM-66 at 300โ600mg/day is the most researched form.
Most RCTs show meaningful effects on cortisol and stress at 8 weeks. Sleep benefits can appear in 2โ4 weeks. Strength gains (when combined with resistance training) become measurable around 6โ8 weeks. Consistency matters more than timing โ take it daily.
The clinical trials show benefits with either timing. For sleep, taking 300mg 1 hour before bed is supported by RCT data. For cortisol and performance, split dosing (morning + evening) or a single morning dose with food works well. Avoid taking on an empty stomach as it can cause mild GI discomfort.
Several RCTs show modest increases in testosterone in healthy men โ typically 10โ22% above baseline. The effect is thought to be indirect: cortisol suppression reduces stress-related testosterone inhibition. Not a replacement for addressing fundamental hormone issues, but meaningful as an adaptogen.
Human trials up to 12 weeks show a good safety profile. Rare cases of liver injury have been reported (likely idiosyncratic, not dose-dependent). Not recommended during pregnancy. People with thyroid conditions should consult a doctor as ashwagandha may affect thyroid hormone levels. Cycle use (8 weeks on, 4 weeks off) is a conservative approach.