Our pick
Legion Triumph
Sport Multivitamin
- Every dose disclosed
- No proprietary blend
Code nunopa — BOGO 50% off your first order
Read the full review →Longevity Supplements
Longevity Supplements
Longevity supplement research focuses on compounds that target the biological hallmarks of aging: NAD+ decline, cellular senescence, oxidative stress, and inflammation.
Running until 18 September 2026
Legion's Labor Day sale is live: buy one, get the second 50% off sitewide, and orders over $119 add free gifts. Verified on their store on 5 September 2026. We earn a commission if you buy through us.
Where we send readers now
We no longer earn commission on any competing supplement brand on this page. The only supplement link we earn from is Legion, below — so you can weigh our ranking above knowing exactly where our money comes from.
Also from Legion
Legion Genesis
Greens Powder
- Every dose disclosed
Code nunopa — BOGO 50% off your first order
Also from Legion
Legion Triton
Fish Oil
- Triglyceride-form omega-3
- Third-party tested
- Every dose disclosed
Code nunopa — BOGO 50% off your first order
Read the full review →
Also from Legion
Legion Fortify
Joint Support
- Every dose disclosed
- No proprietary blend
Code nunopa — BOGO 50% off your first order
Disclosure: every product here is a Legion product and we earn a commission if you buy through these links, at no extra cost to you. The link is what credits us; the code is what gets you the discount, so use both. Our dosing guidance comes from published human trials and is not changed by the commission.
Explore
What the Research Says
RCT · Trammell et al., 2016
NR raises blood NAD+ by 2.7× safely in middle-aged adults
250–500mg NR daily for 6 weeks significantly and safely raised circulating NAD+ levels, confirming oral NR as an effective NAD+ precursor in healthy adults.
PMID 28904226 →Review · Madeo et al., 2018
Spermidine extends lifespan across model organisms
Spermidine supplementation extends lifespan in yeast, flies, worms, and mice via autophagy induction. Human epidemiological data links dietary spermidine intake with lower all-cause and cardiovascular mortality.
PMID 30006480 →Review · Xu et al., 2018
Senolytic compounds (fisetin, quercetin) clear senescent cells
Fisetin and quercetin selectively eliminate senescent cells (zombie cells that secrete inflammatory signals) in animal models. Human pilot data shows transient reduction in senescent cell burden after intermittent fisetin dosing.
PMID 24778258 →Review · Baur & Sinclair, 2006
Resveratrol activates SIRT1 and mimics caloric restriction
Resveratrol activates the NAD+-dependent deacetylase SIRT1, promoting similar gene expression patterns to caloric restriction in animal models. Human bioavailability is limited without micronized or NMX-enhanced formulations.
PMID 20876392 →Frequently Asked Questions
What are the most evidence-backed longevity supplements?
By current evidence: NR/NMN (NAD+ precursors, human RCTs), Omega-3 EPA+DHA (cardiovascular, inflammatory, muscle), Vitamin D3+K2 (mortality data, bone, immune), Magnesium (metabolic, sleep, all-cause mortality), Berberine (metabolic health, AMPK). More speculative: Spermidine, Fisetin, Quercetin, Resveratrol — strong mechanistic data, limited human RCT evidence.
What is the difference between NMN and NR?
Both are NAD+ precursors. NR (nicotinamide riboside) has more completed human RCTs (12+) showing sustained NAD+ elevation. NMN has emerging human data including a 2022 RCT. NR uses a passive transporter for absorption; NMN requires the SLCO4C1 active transporter. In practice, both effectively raise NAD+ — NR has more clinical validation, NMN has more anecdotal following.
What is a senolytic supplement?
Senolytics are compounds that selectively kill senescent cells — aged, damaged cells that stop dividing but resist apoptosis (programmed death) and instead secrete pro-inflammatory signals (the 'SASP'). Senescent cell burden increases with age and contributes to tissue dysfunction. Fisetin and quercetin are the most studied natural senolytics. Intermittent dosing (loading doses over 2–3 days per month) rather than daily supplementation is the studied protocol for senolytics.
At what age should I start longevity supplements?
NAD+ decline is measurable from ~35–40 and accelerates thereafter — NR/NMN is most relevant from 40+. Omega-3, vitamin D, and magnesium are beneficial at any adult age. Senolytic interventions (fisetin, quercetin) target processes that become significant from 50+. Sleep optimization, resistance training, and Zone 2 cardio have larger effect sizes than any supplement stack — prioritize those first.
Telehealth · United States
The NAD+ question, specifically
NAD+ precursors are the most heavily marketed thing in this category and among the least tested for outcomes — 32 randomised trials for nicotinamide riboside, of which four measured anything about the person taking it.
If you want it done with baseline bloods and a provider rather than bought on trust, Pallas runs it as a supervised programme.
The Iron Verdict earns a commission if you subscribe. It changes nothing above — including the part saying four trials is not enough to settle this.
See the NAD+ programme →Available in the United States only. Not medical advice, and not a recommendation to take anything.