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Omega-3

Guides, research reviews, comparisons, product recommendations and FAQs for omega-3.

Updated 2026-06-09Reading time: 5 minReviewed by The Iron Verdict Research Desk

Which fish oil to buy

Most bottles advertise grams of fish oil, not grams of EPA and DHA, which is how a large number on the front becomes a small dose in the softgel. The comparison page reads the two numbers that matter on each label.

See the fish oil labels compared โ†’
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Legion Triton packaging
Our pick ยท Legion
Legion Triton
Fish Oil
  • Triglyceride-form omega-3
  • Third-party tested
  • Every dose disclosed
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Start with Omega-3

What the Research Says

Meta-Analysis ยท Marik & Varon, 2009
Omega-3 reduces cardiovascular mortality by 20%
Meta-analysis of 11 RCTs (n=39,044): omega-3 supplementation significantly reduced cardiovascular mortality (RR 0.80) and sudden death (RR 0.68). Effect strongest with EPA+DHA at 1โ€“4g/day.
PMID 17893723 โ†’
RCT ยท Smith et al., 2011
Omega-3 supplementation increases muscle protein synthesis rates
6-week omega-3 supplementation (4g EPA+DHA/day) significantly increased the anabolic response of skeletal muscle to amino acid + insulin infusion in healthy adults, via mTORC1 signaling.
PMID 16531187 โ†’
Review ยท Kiecolt-Glaser et al., 2011
Omega-3 reduces inflammatory markers (CRP, IL-6) in RCTs
Multiple RCTs show EPA+DHA supplementation (1.8โ€“4g/day for 8โ€“12 weeks) significantly reduces serum CRP, TNF-ฮฑ, and IL-6 โ€” key inflammatory markers linked to chronic disease and exercise-induced inflammation.
PMID 20300002 โ†’
RCT ยท Rodacki et al., 2012
Omega-3 improves muscle torque recovery in older women
3g/day omega-3 for 90 days significantly improved peak torque, muscle quality, and functional capacity in older women, suggesting a protective effect against age-related muscle decline.
PMID 25045870 โ†’

Frequently Asked Questions

How much omega-3 per day?

For general health: 1โ€“2g EPA+DHA daily covers most cardiovascular and anti-inflammatory benefits. For therapeutic use (joint pain, hypertriglyceridemia, depression): 2โ€“4g EPA+DHA/day under medical guidance. The label shows 'omega-3' (total) vs EPA+DHA content โ€” prioritize the EPA+DHA number, not the total fish oil amount. A 1000mg fish oil softgel typically provides only 300mg EPA+DHA.

Fish oil triglyceride vs ethyl ester โ€” does it matter?

Yes, significantly. Triglyceride (TG) form has ~70% better absorption than ethyl ester (EE) form. Most cheap fish oils use EE form due to lower production cost. Look for 'triglyceride form' or 're-esterified triglycerides' on the label. Nordic Naturals, Carlson, and Sports Research use TG form. If taking EE form, take with a high-fat meal to close the absorption gap.

What is the difference between EPA and DHA?

EPA (eicosapentaenoic acid) is primarily anti-inflammatory โ€” it competes with arachidonic acid, reducing pro-inflammatory eicosanoids. Best for: cardiovascular health, depression, exercise recovery. DHA (docosahexaenoic acid) is structural โ€” it makes up ~40% of polyunsaturated fatty acids in the brain and retina. Best for: cognitive function, fetal brain development, vision. For general health, a roughly equal EPA:DHA ratio is fine. For depression, higher EPA ratio (2โ€“3:1 EPA:DHA) shows stronger evidence.

Can I get enough omega-3 from food?

Yes, if you eat fatty fish 2โ€“3ร—/week. Sardines (1 can: ~1800mg EPA+DHA), wild salmon (3oz: ~1500mg), mackerel (3oz: ~2200mg). ALA from plant sources (flaxseed, walnuts, chia) converts poorly to EPA/DHA (<10% conversion in most adults) โ€” not a substitute. Vegans/vegetarians need algae-derived DHA/EPA supplements, which are the original source fish accumulate their omega-3 from.

Does omega-3 help with muscle recovery?

Yes โ€” via anti-inflammatory mechanisms. EPA+DHA supplementation (2โ€“3g/day) has been shown to reduce exercise-induced DOMS, muscle damage markers (CK, LDH), and inflammatory cytokines post-exercise. The anabolic mechanism (mTORC1 sensitization to amino acids, per Smith et al.) adds a second recovery benefit. 3โ€“4 weeks of supplementation before a demanding training block is a reasonable priming strategy.